Guide for Slay The Spire (2024)

Bosses

Each Act in StS ends in a boss. Each Act has three possible bosses except for Act 4 which has only one. When you start a new Act you can look at the map to see which boss you will be facing, as they each have a unique icon. After Ascension 4 bosses do more damage, and after Ascension 9 they have more hit points.

Each boss in Acts 1-3 has an achievement tied to beating it for the first time. Beating the final boss in Act 4 with a given character the first time will also give you an achievement.

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Exactly how you beat the bosses depends entirely on your characters, what cards you've picked up, relics, potions etc. and so no exact guide is possible. I will offer some advice on how you should approach each boss, and refer you to the wiki for complete movesets.

Beating any Act 3 boss with any character for the first time will unlock:

  • Ascend 0

    Unlock Ascension mode.

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Beating any Act 3 boss with any character on Ascension 10 will unlock:

  • Ascend 10

    Complete Ascension Level 10.

    Guide for Slay The Spire (4)

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Beating any Act 3 boss with any character on Ascension 20 will unlock:

  • Ascend 20

    Complete Ascension Level 20.

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Act 1 bosses

The Guardian

This boss has 240 base health. The first turn of combat he will always block so this is a good time to do a lot of damage or set up for later turns. Avoid his stronger attacks by dealing enough damage to force him into defensive mode. Generally, fewer cards that cause more damage are better than more but lower damage cards. This is especially true when he is in defensive mode and causes three damage to you every time you attack him, so make sure you have some block present if you do attack him in that state.

When you beat The Guardian for the first time, you will receive:

  • The Guardian

    Defeated the Guardian.

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Hexaghost

This boss has 250 base health. The first turn of combat it will always do nothing so this is a good time to do a lot of damage or set up for later turns. In the second turn it deals the most damage he ever will, so good block here is very helpful. Thereafter it will either only attack, attack and put burns into your deck, or buff itself. After the second turn, try to attack as much as possible while mitigating damage if you can. The burns will quickly clog up your deck as well as causing you damage so finish it quickly.

When you beat Hexaghost for the first time, you will receive:

  • The Ghost

    Defeated Hexaghost.

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Slime Boss

This boss starts with 140 (150) health. When it gets to half health it will divide into two slimes that have the same health as the divided slime. For example, if you reduce the boss to 70 health then he will split into two slimes with 70 health. Get his health down to 50, and the two slimes will have 50 health each. When it splits, it will interrupt whatever action it is doing. Reduce those two slimes to half health and they will again split into two more slimes, again with the same health as the split slime.

For the first two turns the boss will do nothing, but will then hit you for quite a lot of damage. Therefore, getting it down to half health by the end of your turn 3 is a good idea. But getting it to as low health as possible is better, because then it makes all the subsequent slimes easier to fight. The slimes add Slimed status cards to your deck, clogging it up. Attacks that hit all enemies are useful for this boss, as you might be fighting four small slimes by the end of the combat.

When you beat Slime Boss for the first time, you will receive:

  • The Boss

    Defeated the Slime Boss.

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Act 2 bosses

Bronze Automaton

This boss has 300 (320) health. He will spawn two minions on turn 2 that will either attack you or steal your rarest card(s). Killing the minion returns the card to your deck immediately. The Automaton himself will not attack the first turn while he is spawning minions, and will thereafter attack, boost himself, attack again, boost himself again, and then use his annoyingly powerful Hyper Beam attack. At this point the sequence will start again.

Getting rid of the minions quickly is a good idea to avoid losing potentially your best cards, but you need to ramp up your damage quickly enough to kill the Automaton before he uses his Hyper Beam, or have enough defence to block 45 (50) damage.

When you beat the Bronze Automaton for the first time, you will receive:

  • The Automaton

    Defeated the Bronze Automaton.

    Guide for Slay The Spire (21)

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The Champ

This boss has 420 (440) health. Every four turns he will taunt you and apply debuffs to your attack and defence. He can also metallicize himself to gain block at the end of every turn, and can also increase his own strength. In general will just keep whacking you while giving you those darn debuffs. Because his strength goes up quite quickly, the longer the fight goes on the more dangerous it becomes. When he drops below half health he enters Phase 2 where every third move is a big attack, and the other moves are either debuffs to the player, buffs to himself, or smaller attacks. Working out when to change his phase can help you in this fight. Try to get him as close to half health as possible and then line up some massive damage to drop it down as far as possible before the next phase starts in a similar way to the Slime Boss. Anything that can buff you or prevent The Champ's debuffs from affecting you are useful.

When you defeat The Champ for the first time, you will receive:

  • The Champion

    Defeated the Champ.

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The Collector

This boss has 282 (300) health. Another multi-enemy fight, but luckily The Collector's minions don't steal your cards - they only attack you for relatively low damage. He will keep spawning them though, but that's OK because if he's spawning his minions then he isn't attacking. He might also apply big debuffs to you or big buffs to him and his buddies, and if he does the latter then be careful because the low damage they normally do soon ramps up. Keep on attacking The Collector when he is spawning or (de)buffing, and keep on taking out the minions as needed, while blocking as the big baddie attacks.

When you beat The Collector for the first time, you will unlock:

  • The Collector

    Defeated the Collector.

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Act 3 bosses

Awakened One

This boss has 300 (320) health. He has two minions that start the fight with him but do not respawn, and he also has two phases. His main quirk is that in his first phase only his strength increases every time you play a Power card. Any Power-heavy deck will have more trouble than usual, therefore. In this case try to play only the most useful power cards at the beginning, and save some for the second phase. He doesn't play any debuffs or buffs except for the strength gain, and will keep on pummelling you every turn. In the second phase one of his attacks introduces an unplayable status card to your deck that reduces your energy. Despite all this, he is not so hard. Kill the minions first and block sufficiently while using your remaining energy to attack. If you don't play Power cards, he doersn't get any stronger but can still pack a punch.

When you defeat Awakened One for the first time you will receive:

  • The Crow

    Defeated the Awakened One.

    Guide for Slay The Spire (30)

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Time Eater

This boss has 456 (480) health. His special power is Time Warp, meaning that every 12 cards you play he will end your turn immediately and gain 2 strength. You need to try to play your cards to maximize those 12 you can play before your turn will end. So playing four cards three times might work better than playing five cards twice but then only two on your third turn. Decks that have a lot of low-cost cards might find this fight harder than decks with fewer more expensive cards. Upon falling under half health he will remove all his debuffs and heal back to half health. Therefore, on the turn that you drop him below half health you should play Power or other setup cards since any more damage you do to him that turn ultimately has no effect unless you can kill him. One thing to note is the Watcher card called Vault, which lets you have another turn immediately after your current one. If you play this card as number 12 on Time Eater's counter, it will reset the counter and you will be able to have another turn and play 12 more cards before he buffs.

When you defeat Time Eater for the first time you will receive;

  • The Time Eater

    Defeated the Time Eater.

    Guide for Slay The Spire (33)

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Donu and Deca

These bosses have 250 (265) health each). These two jokers take turns attacking and buffing themselves or applying block. Deca (on the left) will first attack and simultaneously clog your hand with unwanted status cards, and then apply block to both of them and then repeat the short sequence. Donu will first apply strength to them both and then attack the turn after. It's best to concentrate your attacks on one of them: Deca if you find it hard to deal with the extra status cards and lack card draw; Donu to avoid having to block exponentially higher attacks.

The first time you beat Donu and Deca you will receive:

  • The Shapes

    Defeated Donu & Deca.

    Guide for Slay The Spire (36)

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There is an achievement for killing Donu with the Feed card. Like many achievements, this is quite RNG-dependent. You first have to obtain a copy of Feed during your run, then get Donu and Deca as your Act 3 boss, and then be good or lucky enough to be able to play the card to kill the boss. If you manage to do all that you will receive:

  • Ooh Donut!

    Finish Donu with a Feed.

    Guide for Slay The Spire (39)

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The first time you beat any Act 3 boss with a given character, you will receive an achievement:

  • Ruby

    Beat the game with the Ironclad.

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  • Sapphire

    Beat the game with the Defect.

    Guide for Slay The Spire (45)

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  • Emerald

    Beat the game with the Silent.

    Guide for Slay The Spire (48)

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  • Amethyst

    Beat the game with the Watcher

    Guide for Slay The Spire (51)

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Act 4 boss

The Corrupt Heart

This boss has 750 (800) health. As the final boss of the game it is of course quite the challenge. As mentioned previously, to reach this boss you have to collect three coloured keys before you fight the Act 3 boss. After beating that boss you will then enter the final Act which consists of one shop, one campfire, one Elite fight, and the battle against the Corrupt Heart. The heart will always start by applying every possible debuff to you and putting five unwanted status cards into your deck. After turn 4, every three turns it will remove all its own debuffs and give itself strength and extra buffs. The Heart deals damage to you every time you play a card, but only one or two, so if you have a relic or card that reduces damage or strength it will help nullify this effect. It does make decks that need a lot of cards played and card draw to be effective more dangerous, though. Also, because one of its attacks does 2x15 damage, if you have anything that will damage the Heart for each attack he does you can cause significant harm to it passively.

There is an achievement for beating the Corrupt Heart with each character, as well as one for doing so with only Ironclad, Silent, and Defect. When you have defeated the Heart four times, one with each character, you will have received:

  • Ruby+

    Complete the Ending with the Ironclad.

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  • Sapphire+

    Complete the Ending with the Defect.

    Guide for Slay The Spire (58)

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  • Emerald+

    Complete the Ending with the Silent.

    Guide for Slay The Spire (62)

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  • The End?

    Complete the Ending with the Ironclad, Silent, and Defect.

    Guide for Slay The Spire (66)

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  • Amethyst+

    Complete the Ending with the Watcher

    Guide for Slay The Spire (70)

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After these four achievements you never have to face the heart again to complete the game.

Now let's have a look at some more character-specific achievements.

4. Playable Characters2. General hints and tips

Find anything you think is wrong with this walkthrough? Help us fix it by posting in its Walkthrough Thread.

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Guide for Slay The Spire (2024)

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